Human IFN-Alpha 8 (Alpha B2) Protein
Catalog Number: 11115
Human Interferon Alpha 8 recombinant protein expressed in E.coli. (Pack Size: 1 x 10⁵ units)
$335.00
Product Info
Recombinant Human IFN-Alpha B2 (alpha 8) obtained from human leukocyte mRNA expressed in E.coli.
IFN-Alpha 8 is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family. The Type I IFN family has antiviral, anti-proliferative, and natural killer cell activities.
- Expression induced by viral infection
- Encoding gene IFNA8
Specifications
| Formulation | Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA) |
|---|---|
| Molecular Weight | 19.5 kDa |
| Source | cDNA obtained from human leukocyte mRNA expressed in E.coli |
| Purity | > 95% by SDS-PAGE stained by Coomassie Blue |
| Bioactivity | Measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV) |
| Storage | For retention of full activity store at -70 ºC or below and avoid repeated freeze-thaw cycles |
| Synonyms | Hu-IFN-α8 |
| Accession Number | X03125 |
Tech Info & Data
Application Note
- A Comparison of the Binding of Interferon Alpha Subtypes to Isolated IFNAR1 and IFNAR2 with Activity in Antiviral and Antiproliferative Assays (link)
Citations
6 Citations
- Li, Y.,et al., (2023), "An Extracellular Humanized IFNAR Immunocompetent Mouse Model for Analyses of Human Interferon Alpha and Subtypes", Emerg Microbes Infect. 2287681. PMID: 37994664, DOI: 10.1080/22221751.2023.2287681 (link)
- Liu, Qiuzhen, et al. (2014). Melanoma NOS1 expression promotes dysfunctional IFN signaling. JCI, 13 pgs. PMID: 24691438. (link)
- Rompaey, Luc Van, et al. (2013). Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases. Journal of Immunology, 11 pgs. PMID: 24006460. (link)
- Wilson, Timothy R, et al. (2012). Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 12 pgs. PMID: 22763448. (link)
- Kang, Dong-Chul, et al. (2004). Expression Analysis and Genomic Characterization of Human Melanoma Differentiation Associated Gene-5, mda-5: a Novel Type I Interferon-Responsive Apoptosis-Inducing Gene. Oncogene, 12 pgs. PMID: 14676839. (link)
- Yanai, Yoshiaki, et al. (2001). Characterization of the antitumor activities of IFN-alpha8 on renal cell carcinoma cells in vitro. Journal of Interferon & Cytokine Research, 8 pgs. PMID: 11798471. (link)