Human TGF-Beta 3, Human Cell-Expressed (HCE)

Product Features: 
  • Mature disulfide-linked homodimer
  • Purity > 95%
  • Animal-component-free, protein-free production

Ordering

Catalog No. Pack Size Price Quantity
11629-1

5 μg

$272.00
11629-3

100 μg

$2,503.00
11629-4

1000 μg

$9,589.00

Specifications

Formulation Lyophilized from a 0.2 μm filtered solution of 50 mM Sodium Acetate pH 4.5
Molecular Weight 25 kDa, disulfide-linked homodimer, non-glycosylated
Source Human Cell Expressed (HCE) in HEK-293 cells in the absence of animal-derived products
EC50 Typically 0.1 to 0.5 ng/ml
Purity > 95% (SDS-PAGE stained with Coomassie blue)
Endotoxin level < 1 EU/μg
Storage Lyophilized products are stable for one year at -20°C to -80°C from date of receipt. Upon reconstitution, the cytokine can be stored at 4°C for short term only (< 1 week), or at -20°C to -80°C in aliquots for long term. Avoid repeated freeze-thaw cycles. Refreezing should be performed on dry ice or in a dry ice/alcohol bath.

Tech Info / Data

11629 Purity Confirmation on SDS-PAGE
Background: 

Recombinant human TGF beta 3, expressed in engineered human cells, belongs to the TGF beta super family. TGF beta 3 is important for immune homeostasis by balancing lymphocyte proliferation, apoptosis, hematopoiesis and embryogenesis. TGF beta 3 is crucial in cell growth, differentiation and survival. TGF beta 3 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblasts and keratinocytes cells. TGF beta 3 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF beta 3 inhibits NK cell growth as well as B and T cell proliferation.

Citations

Human TGF beta 3 Activity Assay

11629 Activity Assay

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