Human Pro IGF-II, Human Cell-Expressed (HCE)

Product Features: 
  • Authentic glycosylation
  • Animal-component-free, protein-free production
  • Purity > 95%

Ordering

Catalog No. Pack Size Price Quantity
11662-2

10 μg

$174.00
11662-3

100 μg

$483.00
11662-4

1000 μg

$2,834.00

Specifications

Formulation Lyophilized from a 0.2 μm filtered solution of 10 mM Tris pH 7.4, 350 mM NaCl
Molecular Weight 25 kDa, monomer, glycosylated
Source Human Cell Expressed (HCE) in HEK-293 cells in the absence of animal-derived products
EC50 Typically 2 to 8 ng/ml
Purity > 95% (SDS-PAGE stained with Coomassie blue)
Endotoxin level < 1 EU/μg
Storage Lyophilized products are stable for one year at -20°C to -80°C from date of receipt. Upon reconstitution, the cytokine can be stored at 4°C for short term only (< 1 week), or at -20°C to -80°C in aliquots for long term. Avoid repeated freeze-thaw cycles. Refreezing should be performed on dry ice or in a dry ice/alcohol bath.

Tech Info / Data

11662 Purity Confirmation on SDS-PAGE
Background: 

Recombinant human pro-IGF-II, expressed in engineered human cells, belongs to the Insulin-like Growth Factor protein family. In vitro studies show that IGF acts as a potent mitogen for cultured cells and as a physiological amplifier of glucose-mediated insulin secretion. IGF displays osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

Citations

Human pro IGF-II Activity Assay

11662 Activity Assay

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