Human LEFTY-1, Human Cell-Expressed (HCE)

Product Features: 
  • Authentic human glycosylation
  • Animal-component-free, protein-free production
  • High bioactivity and stability

Ordering

Catalog No. Pack Size Price Quantity
11625-2

10 μg

$375.00
11625-3

100 μg

$2,298.00
11625-4

1000 μg

$11,096.00

Specifications

Formulation Lyophilized in 10 mM Tris-HCl pH 7.4, 50 mM NaCl, 0.5% CHAPS
Molecular Weight 38 kDa, monomer, glycosylated
Source Human Cell Expressed (HCE) in HEK-293 cells in the absence of animal-derived products
EC50 Typically 10 to 40 ng/ml
Purity > 90% (SDS-PAGE stained with Coomassie blue)
Endotoxin level < 1 EU/μg
Storage Lyophilized products are stable for one year at -20°C to -80°C from date of receipt. Upon reconstitution, the cytokine can be stored at 4°C for short term only (< 1 week), or at -20°C to -80°C in aliquots for long term. Avoid repeated freeze-thaw cycles. Refreezing should be performed on dry ice or in a dry ice/alcohol bath.

Tech Info / Data

11625 Purity Confirmation on SDS-PAGE
Background: 

Recombinant human left right determination factor (LEFTY-1), expressed in engineered human cells, belongs to the TGF-beta superfamily. LEFTY-1 is required for left-right axis determination as a regulator of LEFTY-2 and NODAL. In the presence of LEFTY-1, LEFTY-2 and NODAL expression is restricted to the left side of organ systems during development. Clinical studies of patients with mutations in LEFTY-1 gene confirm abnormalities in the thorax and cardiac anatomy.

Citations

Human LEFTY-1 Activity Assay

11625 Activity Assay

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