Human IL-7, Human Cell-Expressed (HCE)

Product Features: 
  • Authentic human glycosylation
  • Animal-component-free, protein-free production
  • High bioactivity and stability

Ordering

Catalog No. Pack Size Price Quantity
11606-2

10 μg

$317.00
11606-3

100 μg

$1,706.00
11606-4

1000 μg

$6,140.00

Specifications

Formulation Lyophilized from a 0.2 μm filtered solution of PBS
Molecular Weight 19, 25 and 30 kDa, monomer, glycosylated
Source Human Cell Expressed (HCE) in HEK-293 cells in the absence of animal-derived products
EC50  1 ng/ml
Purity > 95% (SDS-PAGE stained with Coomassie blue)
Endotoxin level < 1 EU/μg
Storage Lyophilized products are stable for one year at -20°C to -80°C from date of receipt. Upon reconstitution, the cytokine can be stored at 4°C for short term only (< 1 week), or at -20°C to -80°C in aliquots for long term. Avoid repeated freeze-thaw cycles. Refreezing should be performed on dry ice or in a dry ice/alcohol bath.

Tech Info / Data

11606 Purity Confirmation on SDS-PAGE
Background: 

Recombinant human interleukin 7 (IL-7), expressed in engineered human cells, is a hematopoietic growth factor secreted by stromal cells, keratinocytes, dendritic cells, hepatocytes, neurons and epthelial cells but is not produced by lymphocytes. It has been shown that IL-7 can also stimulate the proliferation of thymocytes, T-cell progenitors and mature CD4+ and CD8+ T cells, B cells and NK cells. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. Knockout study in mice suggested that IL-7 plays an essential role in lymphoid cell survival. IL-7 has been used as a clinical trial drug against many diseases such as HIV, cancer and transplantation immune recovery.

Citations

Human IL-7 Activity Assay

11606 Activity Assay

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