Human IL-4, Human Cell-Expressed (HCE)

Product Features: 
  • High stability in media for efficient generation of human dendritic cells (DCs)
  • Authentic human glycosylation
  • Animal-component-free, protein-free production

Ordering

Catalog No. Pack Size Price Quantity
11604-2

10 μg

$263.00
11604-3

100 μg

$1,265.00
11604-4

1000 μg

$3,634.00

Specifications

Formulation Lyophilized from a 0.2 μm filtered solution of PBS
Molecular Weight 14 and 19 kDa, monomer, glycosylated
Source Human Cell Expressed (HCE) in HEK-293 cells in the absence of animal-derived products
EC50 Typically 0.1 to 0.5 ng/ml
Purity > 95% (SDS-PAGE stained with Coomassie blue)
Endotoxin level < 1 EU/μg
Storage Lyophilized products are stable for one year at -20°C to -80°C from date of receipt. Upon reconstitution, the cytokine can be stored at 4°C for short term only (< 1 week), or at -20°C to -80°C in aliquots for long term. Avoid repeated freeze-thaw cycles. Refreezing should be performed on dry ice or in a dry ice/alcohol bath.

Tech Info / Data

11604 Purity Confirmation on SDS-PAGE
Background: 

Recombinant human interleukin 4 (IL-4), expressed in engineered human cells, is produced by a number of hematopoietic cell types such as Th2, NK-T, CD3+, as well as basophils, eosinophils and mast cells. Human IL-4 is important in several B-cell and T-cell actiation pathways such as differentiation and proliferation. IL-4 aids antigen presentation on B cells by increasing expression of class II MHC and is implicated in isotype switching of immunoglobulins. Secretion and cell surface expression of IgE and IgG1 and B-cells is enhanced by IL-4. IL-4 inhibits the production of inflammatory cytokines such TNF-alpha and IL-1 and prevents the growth of some cancers.

Citations

Human IL-4 Activity Assay

11604 Activity Assay

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