Human IL-23, Human Cell-Expressed (HCE)

Product Features: 
  • Authentic human glycosylation and native human post-translational modifications
  • Insect-component-free, protein-free production
  • High bioactivity and stability

Ordering

Catalog No. Pack Size Price Quantity
11612-2

10 μg

$328.00
11612-3

100 μg

$1,842.00
11612-4

1000 μg

$11,793.00

Specifications

Formulation Lyophilized from a 0.2 μm filtered solution of PBS
Molecular Weight 55 kDa, disulfide-linked heterodimer, glycosylated
Source Human Cell Expressed (HCE) in HEK-293 cells in the absence of animal-derived products
EC50 Typically 2 to 20 ng/ml
Purity > 95% (SDS-PAGE stained with Coomassie blue)
Endotoxin level < 1 EU/μg
Storage Lyophilized products are stable for one year at -20°C to -80°C from date of receipt. Upon reconstitution, the cytokine can be stored at 4°C for short term only (< 1 week), or at -20°C to -80°C in aliquots for long term. Avoid repeated freeze-thaw cycles. Refreezing should be performed on dry ice or in a dry ice/alcohol bath.

Tech Info / Data

Background: 

Recombinant human interleukin 23 (IL-23), expressed in engineered human cells, is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 (19 kDa) and a p40 (43 kDa) subunit. The biological activity of IL-23 has similarities to IL-12 such as the induction of proliferation IFN-γ, and the effects of IL-23 are restricted to memory T-cells. IL-23 promotes production of proinflammatory cytokines and acts in concert with IL-17 to promote an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex and activates the Jak-Stat signaling cascade.

Citations

Purity Confirmation on SDS-PAGE of Human IL-23

11612 Purity Confirmation on SDS-PAGE

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