Human GM-CSF, Human Cell-Expressed (HCE)

Product Features: 
  • High stability in cell culture for efficient generation of Human Dendritic Cells (DCs)
  • Authentic human glycosylation
  • Animal-component-free, protein-free production

Ordering

Catalog No. Pack Size Price Quantity
11617-2

10 μg

$272.00
11617-3

100 μg

$1,706.00
11617-4

1000 μg

$3,634.00

Specifications

Formulation Lyophilized from a 0.2 μm filtered solution of PBS
Molecular Weight 15 to 36 kDa, monomer, glycosylated
Source Human Cell Expressed (HCE) in HEK-293 cells in the absence of animal-derived products
EC50 Typically 0.4 to 2 ng/ml
Purity 95% (SDS-PAGE stained with Coomassie blue)
Endotoxin level < 1 EU/μg
Storage Lyophilized products are stable for one year at -20°C to -80°C from date of receipt. Upon reconstitution, the cytokine can be stored at 4°C for short term only (< 1 week), or at -20°C to -80°C in aliquots for long term. Avoid repeated freeze-thaw cycles. Refreezing should be performed on dry ice or in a dry ice/alcohol bath.

Tech Info / Data

11617 Purity Confirmation on SDS-PAGE
Background: 

Recombinant human GM-CSF, expressed in engineered human cells, belongs to the IL-2 protein family. GM-CSF is produced by a number of different cell types, including activated T-cells, B-cells, mast cells and endothelial cells. GM-CSF is required to develop neutrophilic colonies in vitro and GM-CSF synergizes with EPO in the proliferation of erythroid and megakaryocytic progenitor cells. GM-CSF promotes myeloid differentiation and generates granulocytes (basophils, neutrophils and eosinophils) and macrophage colonies. GM-CSF triggers irreversible differentiation of myeloblasts and monoblasts and also increases the phagocytic capability of macrophages.

Citations

Human GM-CSF Activity Assay

11617 Activity Assay

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