Human BMP-4, Human Cell-Expressed (HCE)

Product Features: 
  • Higher activity than mouse myeloma cell expressed protein (EC50 2 to 10 ng/ml)
  • Authentic human glycosylation
  • Animal-component-free, protein-free production

Ordering

Catalog No. Pack Size Price Quantity
11623-2

10 μg

$304.00
11623-3

100 μg

$2,367.00
11623-4

1000 μg

$7,250.00

Specifications

Formulation Lyophilized from a 0.2 μm filtered solution of PBS
Molecular Weight 34 kDa, disulfide-linked homodimer, glycosylated
Source Human Cell Expressed (HCE) in HEK-293 cells in the absence of animal-derived products
EC50 Typically 2 to 10 ng/ml
Purity > 95% (SDS-PAGE stained with Coomassie blue)
Endotoxin level < 1 EU/μg
Storage Lyophilized products are stable for one year at -20°C to -80°C from date of receipt. Upon reconstitution, the cytokine can be stored at 4°C for short term only (< 1 week), or at -20°C to -80°C in aliquots for long term. Avoid repeated freeze-thaw cycles. Refreezing should be performed on dry ice or in a dry ice/alcohol bath.

Tech Info / Data

Background: 

Recombinant human BMP-4, expressed in engineered human cells, belongs to the bone morphogenetic protein family that is a subgroup of the TGF-beta superfamily. BMP-4 is a glycosylated homodimer with a disulfide linkage. BMP-4 provides ventralizing signals for existing mesoderm and has a crucial role in mammalian hematopoietic stem cells. This cytokine is important in the onset of endochondral bone formation in humans and is expressed from early embryogenesis through adulthood. BMP-4 is essential in epidermal determination, the development of multiple organs, tissue repair, mesenchyme formation and suppression of neural induction.

Citations

Human BMP-4 Activity Assay

11623 Activity Assay

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